Selected MHRF Research Projects

MHRF's project portfolio includes the projects ranging from early-stage medical research and technology development to commercialization and marketing. The following are a few examples of our work, partnerships, and sponsors. 

  This two-pronged MTEC-sponsored research project aims to reduce the cost and time requirements for cumulative micro-trauma musculoskeletal injuries among active-duty military. The project includes in vitro studies in small segment bone tissue to determine the optimal bioelectric stimulation frequency signals to accelerate bone formation while detecting change in multiple bone fixation markers. The study also includes small-medium animal studies to test in vitro frequencies that induce protein changes and mineralization in bone. The corresponding results will be translated in an application for clinical trials. MHRF manages this project with partners Vira Regen and University of Utah. 

 MHRF partnered with SOCOM, Triple Ring, and Arina to execute a Research and Engineering Feasibility Study on the System for Thermogenic Emergency Airway Management (STEAM), a portable, handheld, battery-powered airway management system. STEAM will have the capability to regulate the temperature and humidity of inspiratory air when delivered to a patient by means of manual or automatic positive pressure ventilation.​

MHRF supports DARPA's DARPA Triage Challenge (DTC) program through partnership with University of Maryland Baltimore's PRIME-AI Lab. Research Infrastructure for Trauma with Medical Observations (RITMO) project is the an ongoing 3.5 year effort to collect and process vital signs and sensor data in support of the DTC.  

 The Precision Automated Critical Care Management (PACC-MAN) project developed and refined a platform of autonomous critical care. The software and hardware platform objective was to deliver fluids, drugs, and blood products based on physiologic data streams, utilizing both rule-based and machine learning (ML)-based adaptive algorithms to optimize resuscitation efforts, minimize periods of hypo/hypertension, and optimize resources. 

The Endovascular Perfusion Augmentation for Critical Care (EPACC) project included the research and development of medical care for poly-trauma patients in resource-constrained settings such as prolonged field care and during aeromedical evacuation. EPACC is novel technology utilizing automated modulation of an intra-aortic balloon catheter to augment blood flow and pressure to the heart, lungs and brain, while still maintaining adequate downstream aortic blood flow.

  This project included a study of Disease and Nonbattle Injury (DNBI) definitions to determine the magnitude and the trends of DNBI and to identify and understand the occurrence of DNBI within the military population. The project also included identifying the risk factors associated with increasing or decreasing trends necessary for developing prevention strategies to reduce the public health burden of DNBI

and DNBI-related mortality.